Technology and Development Team for Mammalian Cellular Dynamics

Organisms always receive stimulation from outside and maintain themselves in response to such stimulation through the complex network of signal transduction. Analysis of this mechanism is the way to elucidate bio response mechanism and to characterize bioresource materials. The main goal of our subteam is to develop new techniques for elucidation of signal transduction mechanism on bio response through the analysis of gene and protein expression using microchip array technique and database at each step including genes, cells, tissues and whole bodies. And the final goal is characterization of biological resources collected in RIKEN BRC for improvement of values of each resource and generation of the new models for human diseases.



This team will develop techniques for analysis of programs and networks of biological signaling at each level from genes to whole bodies of various biological resources collected in RIKEN BRC. This team consists of two subteams, BioSignal Integration and Manipulation of Cell Fate.	Head Yuichi OBATA, PH.D. (concurrent)


Organisms always receive stimulation from outside and maintain themselves in response to such stimulation through the complex network of signal transduction. Analysis of this mechanism is the way to elucidate bio response mechanism and to characterize bioresource materials. The main goal of our subteam is to develop new techniques for elucidation of signal transduction mechanism on bio response through the analysis of gene and protein expression using microchip array technique and database at each step including genes, cells, tissues and whole bodies. And the final goal is characterization of biological resources collected in RIKEN BRC for improvement of values of each resource and generation of the new models for human diseases.	Head Takahiro Doi, M.D., PH.D.

Development of the comprehensive integrated system for function profiling and information focusing on analysis of characteristics of biological resources in RIKEN BRC. Development of the high-throughput analysis system at each level from genes to whole bodies of various biological resources collected in RIKEN BRC. Construction of database for providing the information of biological resources collected in RIKEN BRC and network system linked to the other institutes for integration of related information.

Analysis of signal transduction programs and network mechanism of bioresponse through TNF and NF-κB for elucidation of the mechanisms of immune dysfunction diseases. Analysis of the mechanisms of tumorigenesis with NF-κB through elucidation of apoptosis mechanisms. Characterization of various biological resources collected in RIKEN BRC by analysis of expression profiles of genes and proteins.