Ishii Research Collaborative Group

Research Collaborative Group

RIKEN BRC is working closely with Research Collaborative Groups. In Research Collaborative Groups, there are 3 Groups; Ishii Research Collaborative Group, Shinozaki Research Collaborative and Shiroishi Research Collaborative Group.

For normal development of vertebrate via complicated process, certain types of genes should be expressed at specific organs and timing. For biological protection and homeostasis, expression of certain types of genes is also required. Thus, the gene expression, especially transcriptional regulation, is a basis of various biological phenomena. Our group is analyzing the function of transcription factors that play an important role in development, biological protection, and various diseases. We are also trying to clarify the molecular mechanism by which those transcription factors act.

Head
Shunsuke ISHII,
Ph.D.

Fig-1~3

Fig-1:	Transcription factors such as Myb and ATF-2 regulate transcription via interacting with the mediators complex which contains coactivators including CBP or corepressors including Ski. The mediators complex also interacts with nuclear bodies through PML. We are now trying to clarify the molecular mechanism of transcriptional regulation by those multiple factors.
Fig-2:	The mutant mice lacking transcription factor Shn-2 exhibit a defect of T cell development, and have grossly expanded cortices (c) packed with DP cells and rudimentary medullae (m) that would ordinarily be scattered with mature SP cells.
Fig-3:	Rough eye phenotype in the transgenic flies expressing active form of Drosophila Myb (dMyb C). By screening suppressors and enhancers of this rough eye phenotype, we are now trying to identify the regulators of Myb.

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